Chlamydial persistence: beyond the biphasic paradigm.
نویسندگان
چکیده
Chlamydial Persistence: beyond the Biphasic Paradigm Richard J. Hogan, Sarah A. Mathews, Sanghamitra Mukhopadhyay, James T. Summersgill, and Peter Timms* Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia, and Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, Kentucky
منابع مشابه
Transcriptome analysis of chlamydial growth during IFN- -mediated persistence and reactivation
Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role in the pathophysiology of chlamydial disease. Here we describe the chlamydial transcriptome in an in vitro model of IFN-mediated persistence and reactivation from persistence. Tryptophan utilization...
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Persistence, more recently termed the chlamydial stress response, is a viable but non-infectious state constituting a divergence from the characteristic chlamydial biphasic developmental cycle. Damage/danger associated molecular patterns (DAMPs) are normal intracellular components or metabolites that, when released from cells, signal cellular damage/lysis. Purine metabolite DAMPs, including ext...
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Chlamydiae are medically important bacteria responsible for a wide range of human infections and diseases. Repeated episodes of infection promote chronic inflammation associated with detrimental immune system-mediated pathologic changes. However, the true nature of chlamydial pathogenesis may encompass repeated infection superimposed upon persistent infection, which would allow for heightened i...
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BACKGROUND Synovial tissues in patients with Chlamydia associated arthritis are persistently infected by C trachomatis, an organism for which genetic manipulation is not possible. M tuberculosis also engages in persistent infection, and because this bacterium is genetically tractable many groups have been able to define transcriptional characteristics of mycobacterial growth and persistence. ...
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Although the concept of persistence in chlamydial infections has been recognized for about 80 years, there is still very little known about the mechanism by which this occurs. In this review, we revisit an old paradigm, long known to chlamydiologists and veterinarians, that in virtually all hosts of chlamydiae, including mammals and birds, chlamydiae reside in the gastrointestinal tract for lon...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 72 4 شماره
صفحات -
تاریخ انتشار 2004